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Creating a biomimetic algorithm to find epileptogenic areas of the brain

Researchers from the HSE University Centre for Bioelectric Interfaces have designed a new method for detecting diagnostic markers of epilepsy, called interictal spikes, using EEG and MEG. Capable of accounting for various errors and artifacts, this method constitutes a valuable addition to the arsenal of means for automatic analysis of electrophysiological recordings in epilepsy patients, especially when the data are noisy. Precise localization of epileptogenic cortical structures can enhance the effectiveness of neurosurgical interventions. The study is published in the Journal of Neural Engineering.

More than 65 million people worldwide suffer from epilepsy—which in 30% of cases is resistant to pharmacological treatment. Such patients can be helped by the neurosurgical removal of pathological cortical tissue in the epileptogenic zone. The main challenge for neurosurgeons is to localize this zone of about one square centimeter on the cortex area measuring up to 0.2 square meters. Epileptogenic zone localization can be facilitated by observing the brain’s electrical activity to detect events such as interictal spikes, or spike-wave complexes.

Searching for interictal spikes among the multichannel signals reflecting the brain’s electrical activity is a painstaking process that requires trained epileptologists to sift through a large amount of data using continuously evolving spike selection criteria. This is followed by analysis of the spike amplitude distribution over the scalp surface to localize the epileptogenic zone so that a neurosurgical intervention to remove this cortical area may be planned. 

While automated signal processing and mathematical analysis can facilitate the search for interictal spikes, such automation requires the formalization of selection criteria applied by human operators. 

A group of authors from the HSE University Centre for Bioelectric Interfaces and the Moscow University of Medicine and Dentistry named after I. A. Evdokimov developed a signal analysis technique for translating a verbal description of a spike’s shape into a set of easily verifiable logical predicates. 

“In a sense, our algorithm works like a human. Essentially, it helps the epileptologists to verify a set of verbally described spike shape parameters. The biomimetic approach used in our algorithm facilitates human-machine interaction and contributes to practitioner’s trust in the results obtained by the automated analysis, cdc somali culture ” explains Alexei Ossadtchi, Director of the Centre for Bioelectric Interfaces and head of the research team.

Having compared the algorithm’s performance with a number of conventional methods, the authors found the former to be superior to several other well established approaches in processing datasets containing large amounts of high-amplitude artifacts. 

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