Diogo Dalot, Brandon Williams and Mason Greenwood are all expected to start for Manchester United tonight.
The Red Devils head to Derby in the FA Cup fifth round with a quarter-final at Norwich the reward for the winners.
And boss Ole Gunnar Solskjaer is expected to ring the changes with United also still in the Europa League as the season enters its final months.
Sergio Romero could replace David de Gea in goal while Odion Ighalo may be given his first domestic start since signing in January.
And the Evening Standard claim that Dalot, Williams and Greenwood could also start at Pride Park this evening.
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It comes with Daniel James and Aaron Wan-Bissaka likely to miss out with both struggling with knocks.
Winger James missed Sunday’s 1-1 draw at Everton, having picked up a knock in the win over Club Brugge and he could be replaced by Greenwood.
Wan-Bissaka, who played the full 90 minutes against the Toffees, has obtained a back problem with Dalot expected to slot in.
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Williams may be given another chance to impress at left-back having been handed a few opportunities already this season.
United stars Paul Pogba and Marcus Rashford remain on the sidelines.
Solskjaer said: “Yeah [James will] probably miss out on this one as well and Marcus and Paul are still out and I think Aaron might be struggling.
“He's got a test today, but he struggled in our last game against Everton with his back, so he might be out.
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“Paul's still working with the physios outside and he won't be training with the first team until next week.
“So then let's see how long that will take, but he'll need some time to train to get his football fitness back.”
Defenders Axel Tuanzebe and Tim Fosu-Mensah could also feature in Solskjaer’s squad with the pair having played in the U23 win over Stoke on Monday.
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