Premier League bosses have announced 16 new positive cases – which is a new record weekly high.
They confirmed that 1,207 players and staff were tested between Monday, November 9 and Sunday, November 15, and that resulted in the sudden rise.
The previous weekly high figure was 10 and this will set alarm bells ringing especially as the number of tests were down because players were away on international duty and were tested by their national associations.
It will set alarm bells ringing among Premier League clubs that as soon as players are released for international duty then it results in a rush of positive tests.
That is far greater than at any time during Project Restart and will raise a moral debate if the numbers continue to rise.
On Monday night, the Egyptian FA confirmed Arsenal midfielder Mohamed Elneny had tested positive for coronavirus and would have to self isolate.
The 28-year-old's agent Alan Nazmy also took to Twitter to write: "Elneny Positive Cov19 get well soon."
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Elneny joins fellow Egypt star Mohamed Salah in quarantine after the Liverpool forward tested positive for the virus last Friday, days after attending his brother's wedding in Cairo.
While Salah, 28, may return to the United Kingdom on Thursday if he returns a negative coronavirus test, he will play no part in the tie with Leicester on Sunday due to the Premier League's protocols.
Elsewhere, Tottenham right-back Matt Doherty will play no part in Saturday's clash with Manchester City after testing positive for Covid-19 with Republic of Ireland.
The 1,207 tests carried out over the last week is the second-lowest number for the season, due in large part to the international break.
During the first week of the October international break, 1,128 players and staff were tested, though only nine tests returned new positive cases.
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